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Supports computational and experimental research on the structure, dynamics and function of biomolecules, supermolecular assemblies and their interactions.

Supports interdisciplinary research aimed at mechanistic understanding of the structure, function and evolution of cellular and subcellular systems across the tree of life.

Supports research that employs systems biology or synthetic biology approaches to address compelling questions in molecular and cellular biology. Tool development to advance systems and synthetic biology is also supported.

Supports research that designs and builds synthetic or artificial cells or cell-like systems to explore questions about biological function or evolution of life processes, as well as for biotechnology applications.

Supports the establishment of collaborative research centers focused on mathematical sciences at the interface of molecular, cellular and organismal biology. Each center will support education and training, visitor programs, workshops and outreach.

Invites proposals focused on using the Design-Build-Test-Learn capabilities at the Agile BioFoundry to develop testable prototypes based on the latest advances in synthetic engineering biology.

Supports research in mathematical biology that addresses significant biological questions by applying nontrivial mathematics or developing new theories — particularly from foundational mathematics, including artificial intelligence or machine learning.

Supports mid-career or later-stage researchers in molecular and cellular biology to expand or transition their research programs through sabbaticals or other forms of professional development.

Supports research on living systems at the molecular, subcellular and cellular levels. Core areas supported include cellular dynamics and function; genetic mechanisms; molecular biophysics; and systems and synthetic biology.