Designing Synthetic Cells Beyond the Bounds of Evolution (Designer Cells)

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Important Information for Proposers

Any proposal submitted in response to this funding opportunity should be submitted in accordance with the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. The NSF PAPPG is regularly revised and it is the responsibility of the proposer to ensure that the proposal meets the requirements specified in this solicitation and the applicable version of the PAPPG. Submitting a proposal prior to a specified deadline does not negate this requirement.

Supports research that designs and builds synthetic or artificial cells or cell-like systems to explore questions about biological function or evolution of life processes, as well as for biotechnology applications.

Synopsis

Because of recent technological advances in synthetic biology and bioengineering, researchers are now able to tailor cells and cell-like systems for a variety of basic and applied research purposes. The goal of this solicitation is to support research that (1) develops cell-like systems to identify the minimal requirements for the processes of life, (2) designs synthetically-modified cells to address fundamental questions in the evolution of life or to explore biological diversity beyond that which currently exists in nature, and (3) leverages basic research in cell design to build novel synthetic cell-like systems and cells for innovative biotechnology applications.  

Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. Proposals submitted to this solicitation should address social, ethical, and safety issues associated with designing and building synthetically modified cells as an integrated component of the project.

Program contacts

Anthony G. Garza
aggarza@nsf.gov (703) 292-8440 BIO/MCB
Steven W. Peretti
speretti@nsf.gov (703) 292-7029 ENG/CBET
Senay Agca
sagca@nsf.gov (703) 292-2459

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