Molecular Foundations for Biotechnology (MFB)

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Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 22-1), is effective for proposals submitted, or due, on or after October 4, 2021. Please be advised that, depending on the specified due date, the guidelines contained in NSF 22-1 may apply to proposals submitted in response to this funding opportunity.

Partnerships to Transform the Industries of the Future


This initiative calls for fundamentally new approaches in chemistry to drive new directions in biotechnology, an important Industry of the Future (IotF). Collaborative high risk/high reward projects are sought; the research must involve innovative chemistry.

A multi-year campaign is envisioned (contingent on availability of funding), targeting broad annual themes. This year’s solicitation calls for synergistic scientific partnerships grounded in the principles of synthetic, physical organic and molecular recognition chemistry creating novel chemical biology tools to drive innovations in biotechnology.  The focus is on the development and deployment of fundamentally new techniques to modify the structure, function and/or fate of proteins interacting with small molecules for important applications in biotechnology.

Program Contacts

Tingyu Li (703) 292-4949 MPS/CHE
Herman O. Sintim (703) 292-7244 MPS/CHE
Kelsey D. Cook (703) 292-7490 MPS/CHE

Awards Made Through This Program

Browse projects funded by this program
Map of recent awards made through this program