Genetic Mechanisms

Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 22-1), is effective for proposals submitted, or due, on or after October 4, 2021. Please be advised that, depending on the specified due date, the guidelines contained in NSF 22-1 may apply to proposals submitted in response to this funding opportunity.

Supports research on the fundamental mechanisms involved in the organization, dynamics, processing, expression, regulation and evolution of genetic and epigenetic information.


Apply to NSF 21-509

The cluster supports inventive research to address fundamental mechanisms involved in the organization, dynamics, processing, expression, regulation, and evolution of genetic and epigenetic information. Cross-disciplinary and collaborative research is encouraged, especially when perspectives and quantitative approaches from computational, mathematical, chemical and physical sciences, and engineering are used.  Development of creative technological solutions is also welcome, when driven by the potential to produce significant new knowledge about genetic mechanisms. Projects that are primarily descriptive are given lower priority.

Proposals in the following areas are of particular interest:

  • Principles governing the spatiotemporal organization and coordination of processes that maintain, replicate, transcribe, and translate genomic information.
  • Predictive studies of the relationship of genomic and epigenomic determinants to molecular- or cellular-scale phenotypes.
  • Investigations of the evolutionary origins and functions of genes and genomes.

The following NSF priorities might be of interest to the Genetic Mechanisms community:

  • NSF Big Ideas: Understanding Rules of Life, Navigating the New Arctic, and NSF INCLUDES.
  • Industries of the Future: Biotechnology/Bioeconomy, Artificial Intelligence, and Advanced Manufacturing.

Investigators are welcome to contact GM program directors for further information.

Program contacts

Manju Hingorani 703-292-7323 BIO/MCB
Stephen DiFazio (703) 292-4517 BIO/MCB
Arcady R. Mushegian (703) 292-8528 BIO/MCB
Clifford Weil (703) 292-8712 BIO/MCB

Awards made through this program

Browse projects funded by this program
Map of recent awards made through this program