Supports research on the fundamental mechanisms involved in the organization, dynamics, processing, expression, regulation and evolution of genetic and epigenetic information.
The Genetic Mechanisms (GM) cluster seeks inventive ideas and research to address fundamental questions about genetics, epigenetics, and gene expression mechanisms in diverse organisms. The cluster encourages cross-disciplinary and collaborative research, especially employing perspectives and approaches from computational, mathematical, chemical, and physical sciences and engineering. Creative tool development to address new or long-standing questions about genetic mechanisms is welcome. Primarily descriptive projects are given lower priority.
The cluster encourages research on predictive understanding of:
- The spatiotemporal organization, coordination and/or regulation of processes that maintain, replicate, transcribe and translate the genome;
- Relationships between genomic or epigenomic determinants and molecular or cellular phenotypes;
- Transcriptomic, epitranscriptomic, and other RNA-based regulatory mechanisms;
- Structure-function relationships, interactions, and reactions of macromolecules involved in genetic and epigenetic processes; and
- Mechanisms of evolution of genes and genomes.
Investigators are encouraged to contact GM Program Directors with project ideas or to seek any further information.