Enabling Discovery through GEnomics (EDGE)

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Important Information for Proposers

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 22-1), is effective for proposals submitted, or due, on or after October 4, 2021. Please be advised that, depending on the specified due date, the guidelines contained in NSF 22-1 may apply to proposals submitted in response to this funding opportunity.


Through the Enabling Discovery through GEnomics (EDGE) program, the National Science Foundation (NSF) and the National Institutes for Health (NIH) support research to advance understanding of comparative and functional genomics.  The EDGE program supports the development of innovative tools, technologies, resources, and infrastructure that advance biological research focused on the identification of the causal mechanisms connecting genes and phenotypes. The EDGE program also supports functional genomic research that addresses the mechanistic basis of complex traits in diverse organisms within the context (environmental, developmental, social, and/or genomic) in which they function.  These goals are essential to uncovering the rules that underlie genomes-to-phenomes relationships and predict phenotype, an area relevant to Understanding the Rules of Life: Predicting Phenotype, one of the 10 Big Ideas for NSF investment.  The goals also support the NHGRI priority to establish the roles and relationships of all genes and regulatory elements in pathways, networks, and phenotypes.

Updates and Announcements

Program Contacts

General inquiries regarding this program should be made to:


For questions about NHGRI interests, contact:

  • Jennifer Troyer, telephone (301) 312-3276, email: jennifer.troyer@nih.gov

National Human Genome Research Institute (NHGRI) 

NHGRI will support the development of resources, approaches, and technologies that will accelerate genomic research on the structure of genomes, the biology of genomes, and the biology of disease; that will use genomics to advance the science of medicine; and that will incorporate genomics to improve the effectiveness of healthcare. NHGRI will also support genomic research in several cross-cutting areas, including the ethical, legal and societal implications of genomics and genetics research, bioinformatics, technology development, and research training and career development.

In general, NHGRI supports studies that provide generalizable methods and knowledge.  Applications for studies relevant only to a particular disease or organ system should be directed to the appropriate Institute or Center. NHGRI strongly encourages potential applicants to contact program staff in the early stages of developing your application. The contact information for the three scientific programs are:

Division of Genome Science: https://www.genome.gov/27550609/division-of-genome-sciences-staff/  

Division of Genomic Medicine: https://www.genome.gov/27550610/division-of-genomic-medicine-staff/

Division of Genomics and Society: https://www.genome.gov/27550080/division-of-genomics-and-society/

Theodore J. Morgan
tmorgan@nsf.gov (703) 292 7868 BIO/IOS
Douglas K. (Patrick) Abbot
dabbot@nsf.gov (703) 292-7820 BIO/IOS
Christopher Balakrishnan
cbalakri@nsf.gov (703) 292-2331 BIO/DEB
Steven E. Ellis
stellis@nsf.gov (703) 292-7876 BIO/DBI
Anthony G. Garza
aggarza@nsf.gov (703) 292-8440 BIO/MCB
Courtney E. Jahn
cjahn@nsf.gov (703) 292-7746 BIO/IOS
Jennifer Troyer
NIH/NHGRI Program Director
jennifer.troyer@nih.gov (301) 312-3276

Awards Made Through This Program

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Map of recent awards made through this program